Enhanced allogeneic cellular responses to mismatched HLA-B antigens results in more efficient killing of HIV infected cells

Academic Article

Abstract

  • Epidemiologic studies have demonstrated that HIV-1 discordant couples who share HLA-B alleles were more likely to transmit HIV-1. These data lead us to hypothesize that individuals who match at both HLA-B alleles should have a reduced allogeneic response than those who are not matched. We observed diminished killing of CD4+ target cells only when HLA-B alleles were matched. We propose that for cell-associated HIV-1 transmission, the ability of the recipient to eliminate infected cells from a donor partner may be enhanced when HLA-B alleles are different between partners. These findings suggest a novel mechanism for protection against HIV infection.
  • Digital Object Identifier (doi)

    Author List

  • Sabbaj S; Scanlon N; Du VY; Wang Y; Tang J; Hunter E; Goepfert PA
  • Start Page

  • 493
  • End Page

  • 497
  • Volume

  • 71
  • Issue

  • 5