Molecular identification of Aspergillus species collected for the transplant-associated infection surveillance network

Academic Article

Abstract

  • A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Balajee SA; Kano R; Baddley JW; Moser SA; Marr KA; Alexander BD; Andes D; Kontoyiannis DP; Perrone G; Peterson S
  • Start Page

  • 3138
  • End Page

  • 3141
  • Volume

  • 47
  • Issue

  • 10