Copper-boosting compounds: A novel concept for antimycobacterial drug discovery

Academic Article

Abstract

  • We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Speer A; Shrestha TB; Bossmann SH; Basaraba RJ; Harber GJ; Michalek SM; Niederweis M; Kutsch O; Wolschendorf F
  • Start Page

  • 1089
  • End Page

  • 1091
  • Volume

  • 57
  • Issue

  • 2