Searching for a successful HDL-based treatment strategy

Academic Article


  • Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using an HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful. © 2013 Elsevier B.V.
  • Digital Object Identifier (doi)

    Author List

  • Reddy ST; Navab M; Anantharamaiah GM; Fogelman AM
  • Start Page

  • 162
  • End Page

  • 167
  • Volume

  • 1841
  • Issue

  • 1