Objectives. We assessed the impact of a theory-based, culturally relevant intervention designed to increase mammography screening among African American women in 8 underserved counties in Alabama. Methods. Using principles derived from the Stages of Change, Community Health Advisor, and Community Empowerment models, we developed strategies to increasemammography screening. Trained volunteers (N=143) provided tailored messages to encourage adoption and maintenance of mammography screening. We collected baseline and follow-up data on 1513 women in the communities targeted for the intervention. Our goal was to decrease the number of women in stage 1 (never screened) while increasing the number of women in stage 2 (infrequently screened) and stage 3 (regularly screened). Results. At baseline, 14% (n=211) of the women were in stage 1, 16% (n=247) were in stage 2, and 70% (n=1055) were in stage 3. After the 2-year intervention, 4% (n=61) of the women remained in stage 1, 20% (n=306) were in stage 2, and 76% (n=1146) were in stage 3. Conclusions. Tailored motivational messages and peer support can increase mammography screening rates for African American women.