MELK-a conserved kinase: functions, signaling, cancer, and controversy.

Academic Article

Abstract

  • Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control. Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated. MELK is expressed in several human cancers and stem cell populations. Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence. These findings have important implications for our understanding of development, disease, and cancer therapeutics. Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control.
  • Published In

    Keywords

  • Cancer, Cancer therapeutics, Cancer-initiating cells, Development, Glioblastoma, Glioma-initiating cells, MELK, Maternal embryonic leucine zipper kinase, Mitotic kinase
  • Digital Object Identifier (doi)

    Author List

  • Ganguly R; Mohyeldin A; Thiel J; Kornblum HI; Beullens M; Nakano I
  • Start Page

  • 11
  • Volume

  • 4