Immunopathophysiology of gastrointestinal disease in HIV infection

Academic Article


  • In summary, gastrointestinal manifestations are a major complication of HIV infection. These manifestations present clinically as early, intermediate, and late-phase enteric illness due to HIV itself or the acquisition of opportunistic infections and neoplasms. HIV-induced defects in lymphocytes and mononuclear phagocytes, which circulate through and populate the gastrointestinal mucosa, and a sequence of HIV-dependent alterations in mucosal integrity represent the fundamental immunopathophysiologic basis for these clinical manifestations.
  • Author List

  • Smith PD; Mai UEH
  • Start Page

  • 331
  • End Page

  • 345
  • Volume

  • 21
  • Issue

  • 2