Reiter's syndrome is characterized by multiple joint arthropathy, and can affect the heart. One manifestation of cardiac involvement is aortic insufficiency that may require valve replacement. Herein is reported a case with rapidly progressive and severe calcification of a bovine pericardial prosthesis seven years after implantation, in the setting of Reiter's syndrome. Based on this experience, it is suggested that echocardiographic evaluations be scheduled more frequently than usual if a bioprosthetic rather than mechanical valve is chosen for a patient with Reiter's syndrome. © Copyright by ICR Publishers 2007.