Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

Academic Article

Abstract

  • The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma cells from subjects acutely infected with HIV-1. The frequencies of somatic mutations were relatively high in these gp41-reactive antibodies. Reverted unmutated ancestors of gp41-reactive antibodies derived from subjects acutely infected with HIV-1 frequently did not react with autologous HIV-1 Env; however, these antibodies were polyreactive and frequently bound to host or bacterial antigens. In one large clonal lineage of gp41-reactive antibodies, reactivity to HIV-1 Env was acquired only after somatic mutations. Polyreactive gp41-binding antibodies were also isolated from uninfected individuals. These data suggest that the majority of gp41-binding antibodies produced after acute HIV-1 infection are cross-reactive responses generated by stimulating memory B cells that have previously been activated by non-HIV-1 antigens. © 2011 Liao et al.
  • Published In

  • jrnl7753  Journal
  • Digital Object Identifier (doi)

    Author List

  • Liao HX; Chen X; Munshaw S; Zhang R; Marshall DJ; Vandergrift N; Whitesides JF; Lu X; Yu JS; Hwang KK
  • Start Page

  • 2237
  • End Page

  • 2249
  • Volume

  • 208
  • Issue

  • 11