Evidence has demonstrated health disparities and poor access to health promotion in persons with intellectual and developmental disabilities (IDD). Many chronic health and secondary conditions can be prevented or improved through health promotion. Given the complexity of pre-existing disability-related conditions/syndromes and comorbidities among individuals with IDD, a personalized health promotion intervention is needed to better promote a healthy lifestyle across the lifespan. To illustrate this approach, we explain a framework that considers the process of including problem identification, needs assessment, developing personalized health programs with goal attainment, and long-term support by accessing community resources. We provide two clinical cases to demonstrate the framework. Samples of existing successful health programs are also described. Information and Communication Technology (ICT) is a growing trend that holds promise for improving access to health promotion programs for individuals with IDD.