Epithelial cells as immune effector cells: The role of CD40

Academic Article


  • Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts. © 2009 Elsevier Ltd. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Dugger K; Lowder TW; Tucker TA; Schwiebert LM
  • Start Page

  • 289
  • End Page

  • 292
  • Volume

  • 21
  • Issue

  • 5