Use of the cockroach antigen model of acute asthma to determine the ammunomodulatory role of early exposure to gastrointestinal infection

Academic Article


  • The increased incidence of asthma over the last 50 years in developed countries has been associated with a decrease in infections acquired early in childhood. These early infections are thought to shape subsequent immune responses. Although there have been multiple clinical associations between gastrointestinal infections and decreased asthma incidence, it has been difficult to move beyond a simple correlation when studying human patients. This section describes an acute asthma model in C57BL/6 mice designed to specifically evaluate the effect of prior gastric Helicobacter colonization and inflammation in a murine model of cockroach allergen-induced asthma. © 2013 Springer Science+Business Media, LLC.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Durham CG; Schwiebert LM; Lorenz RG
  • Start Page

  • 271
  • End Page

  • 286
  • Volume

  • 1032