Mitophagy mechanisms and role in human diseases

Academic Article

Abstract

  • Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes. © 2014 Elsevier Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Redmann M; Dodson M; Boyer-Guittaut M; Darley-Usmar V; Zhang J
  • Start Page

  • 127
  • End Page

  • 133
  • Volume

  • 53