Copy number variations associated with obesity-related traits in African Americans: A joint analysis between GENOA and HyperGEN

Academic Article

Abstract

  • Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m 2). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African-American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs. © 2012 The Obesity Society.
  • Digital Object Identifier (doi)

    Author List

  • Zhao W; Wineinger NE; Tiwari HK; Mosley TH; Broeckel U; Arnett DK; Kardia SLR; Kabagambe EK; Sun YV
  • Start Page

  • 2431
  • End Page

  • 2437
  • Volume

  • 20
  • Issue

  • 12