Low mini-mental status predicts mortality in asymptomatic carotid arterial stenosis. Asymptomatic Carotid Atherosclerosis Study investigators.

Academic Article


  • OBJECTIVE: To determine whether carotid endarterectomy is superior to best medical therapy in preserving cognition, and whether low Mini-Mental State Examination (MMSE) scores predict TIA, stroke, myocardial infarction, or death. METHODS: Subjects participating in the Asymptomatic Carotid Atherosclerosis Study were administered the MMSE at periodic intervals. Group means were calculated at randomization, 1 and 3 months later, and every 6 months thereafter. The group means were compared by treatment and over time. A proportional hazard regression model incorporating postrandomization MMSE score as a predictor variable was used to estimate risk of death, stroke, or other outcome events. RESULTS: There was no intergroup difference in mean MMSE score during 5 years of observation. For individual patients, the relationship between a low postrandomization score on the MMSE and increased risk of death was significant (p
  • Authors

    Published In

  • Neurology  Journal
  • Keywords

  • Carotid Stenosis, Humans, Neuropsychological Tests, Predictive Value of Tests, Prognosis, Regression Analysis, Time Factors
  • Digital Object Identifier (doi)

    Author List

  • Pettigrew LC; Thomas N; Howard VJ; Veltkamp R; Toole JF
  • Start Page

  • 30
  • End Page

  • 34
  • Volume

  • 55
  • Issue

  • 1