Reduction in the urinary aflatoxin M1 biomarker as an early indicator of the efficacy of dietary interventions to reduce exposure to aflatoxins

Academic Article


  • Aflatoxin B1 is a persistent public health issue in Ghana. Assessment of AFB1 intervention efficacy is currently dependent on long-term biomarkers. This study was designed to determine whether daily AFM1 biomarker levels could be utilized as an early detection method for intervention efficacy. Participants were treated with a refined calcium montmorillonite clay (UPSN) or a placebo (calcium carbonate) in a crossover study. Urine samples were assessed for AFM1 levels daily. UPSN treatment reduced AFM1 biomarkers by 55% compared to the placebo. This is the first study to show that daily urinary AFM1 levels can be used as a biomarker of internal aflatoxin B1 exposure in short-term intervention trials to determine efficacy. © 2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
  • Authors

    Published In

  • Biomarkers  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mitchell NJ; Kumi J; Johnson NM; Dotse E; Marroquin-Cardona A; Wang JS; Jolly PE; Ankrah NA; Phillips TD
  • Start Page

  • 391
  • End Page

  • 398
  • Volume

  • 18
  • Issue

  • 5