Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities

Academic Article

Abstract

  • Vaccines designed to bring forth CD8+ T cell responses in different racial and ethnic groups will require inclusion of T cell epitopes presented by various MHC class I molecules. This study was designed to identify new CD8+ T cell epitopes in HIV-infected African American and Hispanic youth as well as to determine the frequency of responses to both novel and previously described HIV-1 epitopes in a cohort of racially and ethnically diverse individuals. We found 8 MHC class I-restricted CD8+ T cell epitopes that had not been previously described, another 8 epitopes that were restricted by class I alleles not previously associated with these epitopes, and 8 additional epitopes that have been described previously. In a larger cohort, we demonstrated that 11 (69%) of these 16 newly described immunogens were recognized by individuals of different race or ethnicity. Most HIV-1-specific CD8+ T cell epitopes identified were either novel or restricted by alternative MHC class I alleles. Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine.
  • Digital Object Identifier (doi)

    Author List

  • Sabbaj S; Bansal A; Ritter GD; Perkins C; Edwards BH; Gough E; Tang J; Szinger JJ; Korber B; Wilson CM
  • Start Page

  • 426
  • End Page

  • 438
  • Volume

  • 33
  • Issue

  • 4