CD8+CD88+ T cells but not HIV type 1 RNA viral load predict CD4+ T cell loss in a predominantly minority female HIV + adolescent population

Academic Article

Abstract

  • The purpose of this study was to evaluate predictors of HIV-1 disease progression in a cohort of predominantly female and minority adolescents who had acquired their HIV-1 infections through sexual risk behaviors. Subjects were identified from the REACH cohort who were not on antiretroviral therapy for at least 1 year and whose baseline CD4+ T cells were >300 cells/mm3 Biomedical and demographic characteristics of the subjects at the start of the study period were evaluated as predictors of CD4 + T cell loss in univariate and multivariate models. Two-thirds of the 99 subjects meeting the selection criteria were female and 87% were black or Hispanic similar to the REACH cohort as a whole. Higher absolute CD8 +CD38+ T cell counts at the start of the assessment period were associated with a greater rate of loss of CD4+ T cells. HIV-1 RNA viral load was among other potential predictors of HIV-1 disease progression that had no association with the rate of CD4+ T cell loss in this cohort. This study extends the observed association of higher CD8+CD38+ T cells numbers being predictive of HIV-1 disease progression into predominantly female, minority youth.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Wilson CM; Ellenberg JH; Douglas SD; Moscicki AB; Holland CA
  • Start Page

  • 263
  • End Page

  • 269
  • Volume

  • 20
  • Issue

  • 3