Prevalence of primary HIV-1 drug resistance among recently infected adolescents: A Multicenter Adolescent Medicine Trials Network for HIV/AIDS Interventions Study

Academic Article

Abstract

  • This study examined the prevalence of primary human immunodeficiency type 1 (HIV-1) drug resistance among recently infected youth in the United States. Of the 55 subjects studied, major mutations conferring HIV drug resistance were present in 10 (18%). Eight (15%) had nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations, with the majority (6) having the K103N mutation; 2 (4%) had nucleoside reverse-transcriptase inhibitor (NRTI) mutations; and 2 (4%) had protease inhibitor (PI) mutations. Phenotypic drug resistance was present in 12 (22%) subjects: 10 (18%) for NNRTIs, 2 (4%) for NRTIs, and 3 (5.5%) for PIs. The prevalence of primary HIV-1 drug resistance, particularly to NNRTIs, in this group of recently infected youth was high. © 2006 by the Infectious Diseases Society of America. All rights reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Viani RM; Peralta L; Aldrovandi G; Kapogiannis BG; Mitchell R; Spector SA; Lie YS; Weidler JM; Bates MP; Liu N
  • Start Page

  • 1505
  • End Page

  • 1509
  • Volume

  • 194
  • Issue

  • 11