Ambulatory blood pressure monitoring in individuals with HIV: A systematic review and meta-analysis

Academic Article


  • Introduction: Abnormal diurnal blood pressure (BP) rhythms may contribute to the high cardiovascular disease risk in HIV-positive (HIV ) individuals. To synthesize the current literature on ambulatory BP monitoring (ABPM) in HIV individuals, a systematic literature review and metaanalysis were performed. Methods; Medical databases were searched through November 11, 2015 for studies that reported ABPM results in HIV individuals. Data were extracted by 2 reviewers and pooled differences between HIV and HIV negative (HIV ) individuals in clinic BP and ABPM measures were calculated using random-effects inverse variance weighted models. Results: Of 597 abstracts reviewed, 8 studies with HIV cohorts met the inclusion criteria. The 420 HIV and 714 HIV individuals in 7 studies with HIV comparison groups were pooled for analyses. The pooled absolute nocturnal systolic and diastolic BP declines were 3.16% (95% confidence interval [CI]: 1.13%, 5.20%) and 2.92% (95% CI: 1.64%, 4.19%) less, respectively, in HIV versus HIV individuals. The pooled odds ratio for non-dipping systolic BP (nocturnal systolic BP decline <10%) in HIV versus HIV individuals was 2.72 (95% CI: 1.92, 3.85). Differences in mean clinic, 24-hour, daytime, or nighttime BP were not statistically significant. I and heterogeneity chi-squared statistics indicated the presence of high heterogeneity for all outcomes except percent DBP dipping and non-dipping SBP pattern. Conclusions: An abnormal diurnal BP pattern may be more common among HIV versus HIV individuals. However, results were heterogeneous for most BP measures, suggesting more research in this area is needed. + + + + - - + + - - + - + - 2 + -
  • Published In

  • PLoS ONE  Journal
  • Digital Object Identifier (doi)

    Author List

  • Kent ST; Bromfield SG; Burkholder GA; Falzon L; Oparil S; Overton ET; Mugavero MJ; Schwartz JE; Shimbo D; Muntner P
  • Volume

  • 11
  • Issue

  • 2