Introduction Single-incision pediatric endosurgery (SIPES) is gaining popularity and has been reported to be safe in acute (non-perforated) and perforated appendicitis. The feasibility of SIPES appendectomy in obese children is uncertain. Materials and methods After IRB approval, data were collected from a prospectively maintained SIPES appendectomy database for cases performed between April 2009 and March 2012. Patients were divided into obese and non-obese groups based on Center for Disease Control criteria. The surgical techniques, operative times, complications, conversion rates, and outcomes were recorded. Chi-square test and t-test were used for statistical analysis. Results SIPES appendectomy was attempted in 500 children. There were 21% obese, and 37% were female with median age of 10.9 ± 3.8 years. Mean operative time, blood loss, requirement of additional trocars, and intraoperative complications in non-obese and obese children were not significantly different. Mean hospital stay (2.3 days in each group), post operative wound infections (3.3% vs. 4.8%, p = 0.55, non-obese vs. obese), and intraabdominal abscesses (4.3% vs. 2.9%, p = 0.77, non-obese vs. obese) were not significantly different. Conclusion SIPES appendectomy may be accomplished successfully and safely in obese children. Obesity did not appear to be associated with increased risk of complications and was not a contraindication for SIPES appendectomy. © 2013 Elsevier Inc.