IL-1R/TLR2 through MyD88 divergently modulates osteoclastogenesis through regulation of nuclear factor of activated T cells c1 (NFATc1) and B lymphocyte-induced maturation protein-1 (Blimp1)

Academic Article

Abstract

  • © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A. Background: Interleukin-1 and Porphyromonas gingivalis both signal through the IL-1R/TLR superfamily but have distinct effects on osteoclastogenesis. Results: IL-1 and P. gingivalis lipopolysaccharide (LPS-PG) differentially regulate osteoclast genes and osteoclastogenic transcription factor NFATc1, as well as transcription repressor Blimp1 and anti-osteoclastogenic genes. Conclusion: Multiple signaling molecules are involved in distinct IL-1R/TLR2-mediated effects on osteoclastogenesis. Significance: This is a novel mechanism for understanding infection/inflammation-mediated osteoclastogenesis.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Chen Z; Su L; Xu Q; Katz J; Michalek SM; Fan M; Feng X; Zhang P
  • Start Page

  • 30163
  • End Page

  • 30174
  • Volume

  • 290
  • Issue

  • 50