This study investigated the relationship between race and strain in family caregivers of hospitalized older patients. Data came from a sample of 176 African American and 194 White American caregivers who were identified as part of a prospective study of changes in functional status of older hospitalized patients. When interaction terms were added to a multivariate model assessing the relationship between race and strain, race lost its significant influence on strain. Instead, its combination with two other variables - being an adult child caregiver and being married - emerged as important correlates. Being an adult child had deleterious consequences for White caregivers, whereas being married had advantageous consequences for African American caregivers. Findings emphasize the need to reevaluate how the race variable is used in future research and the need for hospital staff to be sensitive to racial diversity when working with families to plan for older patients' discharge.