NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis

Academic Article


  • To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups that received 3.0 g NS day (high dose, HD), 1.5 g NS day (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Gender-stratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose–time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p < 0.001) in the HD group (male = 113.65 ± 28.00 µg l ; female = 116.40 ± 24.26 µg l ) compared with the PL group (male = 83.55 ± 39.90 µg l ; female = 90.47 ± 25.68 µg l ) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans. © 2008 Taylor & Francis Group, LLC. −1 −1 −1 −1 −1 −1
  • Authors

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    Author List

  • Afriyie-Gyawu E; Wang Z; Ankrah NA; Xu L; Johnson NM; Tang L; Guan H; Huebner HJ; Jolly PE; Ellis WO
  • Start Page

  • 872
  • End Page

  • 884
  • Volume

  • 25
  • Issue

  • 7