Proteogenomic Characterization of Endometrial Carcinoma.

Academic Article

Abstract

  • We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.
  • Authors

    Published In

  • Cell  Journal
  • Keywords

  • CTNNB1, TP53, acetylation, circular RNA, endometrial cancer, endometrioid endometrial cancer, immune evasion, proteogenomics, proteomics, serous endometrial cancer, Acetylation, Animals, Antigens, Neoplasm, Carcinoma, Endometrial Neoplasms, Epithelial-Mesenchymal Transition, Feedback, Physiological, Female, Gene Expression Regulation, Neoplastic, Genomic Instability, Humans, Mice, MicroRNAs, Microsatellite Repeats, Phosphorylation, Protein Processing, Post-Translational, Proteome, Signal Transduction, Transcriptome
  • Digital Object Identifier (doi)

    Author List

  • Dou Y; Kawaler EA; Cui Zhou D; Gritsenko MA; Huang C; Blumenberg L; Karpova A; Petyuk VA; Savage SR; Satpathy S
  • Start Page

  • 729
  • End Page

  • 748.e26
  • Volume

  • 180
  • Issue

  • 4