Maternal and Perinatal Outcomes Associated with the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Academic Article


  • Two years into the coronavirus disease 2019 (COVID-19) pandemic, we have now seen three main variant waves. We performed a retrospective cohort study of all pregnant patients with COVID-19 at our institution from March 22, 2020, to February 26, 2022, to evaluate disease severity and perinatal outcomes among the variants. Patients were categorized as pre-Delta (March 22, 2020-May 31, 2021), Delta (July 1, 2021-December 15, 2021), or Omicron (December 16, 2021-February 26, 2022) based on variant tracking from the Centers for Disease Control and Prevention and genotype sequencing at our institution. There were fewer cases of severe-critical disease (1.8% Omicron vs 13.3% pre-Delta and 24.1% Delta) and adverse perinatal outcomes during the Omicron wave compared with the pre-Delta and Delta waves.
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    Digital Object Identifier (doi)

    Author List

  • Seasely AR; Blanchard CT; Arora N; Battarbee AN; Casey BM; Dionne-Odom J; Leal SM; Moates DB; Sinkey RG; Szychowski JM
  • Start Page

  • 262
  • End Page

  • 265
  • Volume

  • 140
  • Issue

  • 2