Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women

Academic Article

Abstract

  • Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) μg·h/ml, 11.2 (8.0 to 17.5) μg/ml, and 4.6 (1.7 to 12.5) μg/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Cressey TR; Van Dyke R; Jourdain G; Puthanakit T; Roongpisuthipong A; Achalapong J; Yuthavisuthi P; Prommas S; Chotivanich N; Maupin R
  • Start Page

  • 2189
  • End Page

  • 2191
  • Volume

  • 53
  • Issue

  • 5