Protective immunity induced in mice by detoxified salmonella lipopolysaccharide.

Academic Article


  • C3H/HeNMTV mice were immunised intraperitoneally (i.p.) with lipopolysaccharide (LPS) or detoxified LPS (D-LPS) derived from Salmonella typhimurium strain SR-11. In both cases, effective protection was achieved against a challenge dose of greater than 2 x 10(2) LD50 of the same organism given by i.p. injection. However, by comparison with LPS, approximately 6- to 10-fold more of D-LPS by weight was needed to protect mice to an equivalent degree. Histopathological studies showed that the initial lesions in infected mice protected with either LPS or D-LPS were composed of self-limiting abscesses which transformed into granulomas as the animals recovered. It is suggested that D-LPS may be modified to become a highly effective, non-toxic salmonella vaccine.
  • Authors

    Published In


  • Animals, Bacterial Vaccines, Electrophoresis, Polyacrylamide Gel, Granuloma, Lipopolysaccharides, Liver, Male, Mice, Mice, Inbred C3H, Salmonella Infections, Animal, Salmonella typhimurium, Virulence
  • Digital Object Identifier (doi)

    Author List

  • Ding HF; Nakoneczna I; Hsu HS
  • Start Page

  • 95
  • End Page

  • 102
  • Volume

  • 31
  • Issue

  • 2