Mechanisms of p53-mediated apoptosis.

Academic Article

Abstract

  • p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.

    • Authors

    Keywords

  • Animals, Apoptosis, Caspases, DNA-Binding Proteins, Gene Expression Regulation, HLA-DR5 Antigen, Humans, Insulin-Like Growth Factor Binding Protein 3, Neoplasms, Nuclear Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Transcription, Genetic, Tumor Suppressor Protein p53, bcl-2-Associated X Protein, fas Receptor

    • Digital Object Identifier (doi)

    Author List

  • Ding HF; Fisher DE

    • Start Page

  • 83

    • End Page

  • 98

    • Volume

  • 9

    • Issue

  • 1