Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells

Academic Article


  • Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in detail the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1].
  • Authors

    Published In

  • Data in Brief  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wang X; Yang L; Choi JH; Kitamura E; Chang CS; Ding J; Lee EJ; Cui H; Ding HF
  • Start Page

  • 50
  • End Page

  • 52
  • Volume

  • 2