Application of lung volume reduction surgery for a child with filamin A (FLNA) mutations

Academic Article


  • Diffuse lung disease in early childhood due to mutations in the filamin A gene has been recently reported. Clinical outcomes vary among individuals indicating variability in phenotype but a substantial proportion of reported cases in early life have ended up in death or lung transplantation. We recently encountered a school-aged child in whom the diagnosis of a filamin A mutation was delayed and the natural history of emphysematous lung disease was altered by serial lung volume reduction surgeries. She eventually underwent a bilateral lung transplant and we report the natural history of her disease and treatments applied herein.
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    Author List

  • Burrage LC; Heinle JS; Cerfolio RH; Guillerman RP; Patel KR; Santiago NC; Hoover WC; Mallory GB
  • Start Page

  • 224
  • End Page

  • 230
  • Volume

  • 57
  • Issue

  • 1