Bisphenol A and Nongenotoxic Drivers of Cancer



  • Carcinogen exposure induces a wide variety of cellular responses that have been classified into genotoxic and nongenotoxic mechanisms. To illustrate the complexity in evaluating the mechanisms of tumor promotion by a nongenotoxic carcinogen, this chapter examines the toxicant and candidate carcinogen bisphenol A (BPA), a ubiquitous and well-known estrogenic chemical used in consumer goods. The chapter reviews the current literature supporting BPA as a nongenotoxic carcinogen to help further research evaluating the health risks of exposure and to provide a framework from which all potential contributing effects of this toxicant to carcinogenesis may be considered. BPA, like other estrogenic compounds and hormones, shows a nonmonotonic dose response. A common mode of action for nongenotoxic carcinogens is receptor-mediated effects. Chronic inflammation is associated with an increased risk of cancer, and impairment of immune response, whether through immunosuppression or impaired surveillance, can contribute to tumor promotion.
  • Authors

    Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9781119023609
  • Start Page

  • 415
  • End Page

  • 438