Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway

Academic Article


  • This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes to the pathogenesis of many tumor types. Biochemical and genetic aberrations of this pathway observed in various cancer types are explored. Last, pathway inhibitors both in development and already approved by the Food and Drug Administration are discussed. © 2013 Elsevier Inc.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Hassan B; Akcakanat A; Holder AM; Meric-Bernstam F
  • Start Page

  • 641
  • End Page

  • 664
  • Volume

  • 22
  • Issue

  • 4