MicroRNAs in osteosarcomagenesis

Academic Article

Abstract

  • The etiology of osteosarcoma (OS) remains enigmatic. Particular clinical and molecular patterns, observed with high frequency in OS, suggest that it results from some yet-to-be-discovered central driver. How else can biology generate such an aggressive, metastatic, genetically and chromosomally unstable malignancy with virtually no apparent precursor neoplasms that are partway along a disease path toward OS? With this conundrum as a backdrop, the discovery of every new native molecule with power to impact a cell's biology is usually quickly followed by a search to see if this type of molecule contains the key to unlock OS biology.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 1370289
  • Author List

  • Kafchinski LA; Jones KB
  • Start Page

  • 119
  • End Page

  • 127
  • Volume

  • 804