Human cytomegalovirus (HCMV) smallest capsid protein identified as product of short open reading frame located between HCMV UL48 and UL49

Academic Article


  • The capsid of cytomegalovirus contains an abundant, low-molecular- weight protein whose coding sequence within the viral genome had nut been identified. We have used a combination of biochemical and immunological techniques to demonstrate that this protein, called the smallest capsid protein in human cytomegalovirus, is encoded by a previously unidentified 225-bp open reading frame (ORF) located between ORFs UL48 and UL49. This short ORF, called UL48/49, is the positional homolog of herpes simplex virus ORF UL35 (encoding capsid protein VP26) and shows partial amino acid sequence identity to positional homologs in human herpes viruses 6 and 7.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 11419470
  • Author List

  • Gibson W; Clopper KS; Britt WJ; Baxter MK
  • Start Page

  • 5680
  • End Page

  • 5683
  • Volume

  • 70
  • Issue

  • 8