Overexpression of TGF-ß1 in the central nervous system of transgenic mice results in hydrocephalus

Academic Article


  • Transforming growth factor p (TGF-P) has been proposed to play a number of roles in central nervous system (CNS) development and response to injury. To test these proposals, transgenic mice were generated which overproduce TGF-pi in the CNS. Surprisingly, these mice developed severe hydrocephalus and died between birth and 3 weeks of age. Ovary transplantation from an affected female founder has permitted perpetuation of one of the lines as a hydrocephalus model whose genetic defect is known. These results also demonstrate that the developing CNS is highly sensitive to TGF-P, and suggest a role for aberrant expression of TGF-p in the pathogenesis of developmental disease of the CNS. © 1995 by the American Association of Neuropathologists.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 10386066
  • Author List

  • Galbreath E; Kim SJ; Park K; Brenner M; Messing A
  • Start Page

  • 339
  • End Page

  • 349
  • Volume

  • 54
  • Issue

  • 3