A host of innovative developments in technology have led by 2D materials owing to their remarkable electronic and physical properties which opens doors for advanced research areas and horizons of material science. Among these materials, transitional metal dichalcogenides (TMDCs) e.g., MoS2, WS2, MoSe2, and WSe2, are reflected as promising candidates of 2D family. Despite significant achievements, the primary challenge is to produce these 2D materials with high purity, massive yield, and well-controlled structure that lead to fundamental research as well as industrial applications in an efficient and scalable way. A variety of techniques have been employed to develop 2D-TMDCs, such as mechanical exfoliation, chemical vapor deposition, and chemical exfoliations. Among state-of-the-art synthetic protocols, chemical exfoliations including Liquid-phase and intercalation isolations of TMDCs are deliberated as promising solutions for high yield, great performance, low cost, and excellent up-scalability. Herein, a succinct and comprehensive survey of recent progress in chemical exfoliation routes is presented with the processing techniques, strategic design for exfoliations, and mechanisms of individual approaches. The focus of this review is to fulfill the gap in recent reviews such as underlying mechanisms, chemistries, and critical hurdles with effective solutions in performing chemical exfoliations and suggesting a framework for future studies of TMDCs’ advanced applications.