A Primer on Mast Cell Activation Disease for the Nurse Practitioner

Academic Article


  • The primary care literature lacks information on mast cell activation disease (MCAD) and, more specifically, mast cell activation syndrome, yet it affects approximately 17% of the population. Because many providers remain unaware of MCAD, this article provides a primer on mast cell diseases, including triggers, signs and symptoms, diagnosis, treatment, and resources for patients and providers. Primary care nurse practitioners are uniquely positioned and qualified to identify patients with multiple, diffuse complaints and chronic, multisystem symptoms—the hallmark of MCAD—and refer them for further diagnosis and treatment to reduce debilitating symptoms.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Selleck B; Selleck C
  • Start Page

  • 776
  • End Page

  • 780
  • Volume

  • 17
  • Issue

  • 7