Generalization of a genetic risk score for time to first albuminuria in children with sickle cell anaemia: SCCRIP cohort study results

Academic Article


  • Albuminuria predicts kidney disease progression in individuals with sickle cell anaemia (SCA); however, earlier prediction of kidney disease with introduction of reno-protective therapies prior to the onset of albuminuria may attenuate disease progression. A genetic risk score (GRS) for SCA-related nephropathy may provide an improved one-time test for early identification of high-risk patients. We utilized a GRS from a recent, large, trans-ethnic meta-analysis to identify three single nucleotide polymorphisms that associate individually and in a GRS with time to first albuminuria episode in children with SCA.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 26720797
  • Author List

  • Rashkin SR; Rampersaud E; Kang G; Ataga KI; Hankins JS; Wang W; Estepp JH; Weiss MJ; Lebensburger J; Zahr RS
  • Start Page

  • 469
  • End Page

  • 473
  • Volume

  • 194
  • Issue

  • 2