Active immune response protects Stat6VT transgenic mice from developing a lymphoproliferative disorder

Academic Article

Abstract

  • Stat6 is a transcription factor that regulates important cellular processes such as proliferation, differentiation, and survival through mediating IL-4 and IL-13 signaling. Importantly, increasing evidence indicates of a role for Stat6 in lymphoproliferative disorders. Mice expressing a constitutively active form of Stat6 (Stat6VT) primarily in T lymphocytes were generated, and it has been recently described that a small percentage (~5%) of these mice develop a spontaneous lymphoproliferative disorder (LPD) resulting in dramatic splenomegaly and altered splenic cell populations. Here, we report that Stat6VT mice housed in a non-pathogen-free environment have an increased incidence (37%) of the LPD. Additionally, examination of the expression of Stat6-regulated genes known to have roles in tumorigenesis demonstrated that there appears to be no one genetic alteration common to lymphocytes from Stat6VT/LPD mice. Interestingly, however, uniform exposure to antigen via immunization resulted in complete abrogation of the LPD in Stat6VT mice. © 2009 Elsevier GmbH.
  • Published In

  • Immunobiology  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 24411940
  • Author List

  • Crane ED; Stephenson N; Haffner C; Bruns HA
  • Start Page

  • 579
  • End Page

  • 585
  • Volume

  • 215
  • Issue

  • 7