Cercopithecine herpesvirus 1 (B virus)



  • B virus, endemic in macaque monkeys, has the unique distinction of being the only one of nearly 35 identified nonhuman primate herpesviruses that is highly pathogenic for humans. Infection has resulted in over 50 cases, with a mortality in excess of 80% in the absence of therapy. The actual number of cases worldwide is unknown. The unique biology of B virus includes its neurotrophism and neurovirulence. Because untreated B-virus infections are associated with high mortality in humans, individuals handling macaques or macaque cells and tissues are at risk for infection. Human infection is associated with a breach of skin or mucosa and subsequent virus infection. Fomites and contaminated particulates or surfaces can serve as a source of virus infection. Since the early 1980s, 80% of infected individuals given antiviral treatment have survived. Timely antiviral intervention is the only effective means of reducing B-virus-associated morbidity and preventing a fatal outcome.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9781555819422
  • Start Page

  • 447
  • End Page

  • 457