Development and preclinical evaluation of a patient-specific high energy x-ray phase sensitive breast tomosynthesis system

Academic Article


  • Background: This article reports the first x-ray phase sensitive breast tomosynthesis (PBT) system that is aimed for direct translation to clinical practice for the diagnosis of breast cancer. Purpose: To report the preclinical evaluation and comparison of the newly built PBT system with a conventional digital breast tomosynthesis (DBT) system. Methods and materials: The PBT system is developed based on a comprehensive inline phase contrast theoretical model. The system consists of a polyenergetic microfocus x-ray source and a flat panel detector mounted on an arm that is attached to a rotating gantry. It acquires nine projections over a 15° angular span in a stop-and-shoot manner. A dedicated phase retrieval algorithm is integrated with a filtered back-projection method that reconstructs tomographic slices. The American College of Radiology (ACR) accreditation phantom, a contrast detail (CD) phantom and mastectomy tissue samples were imaged at the same glandular dose levels by both the PBT and a standard of care DBT system for image quality characterizations and comparisons. Results: The PBT imaging scores with the ACR phantom are in good to excellent range and meet the quality assurance criteria set by the Mammography Quality Standard Act. The CD phantom image comparison and associated statistical analyses from two-alternative forced-choice reader studies confirm the improvement offered by the PBT system in terms of contrast resolution, spatial resolution, and conspicuity. The artifact spread function (ASF) analyses revealed a sizable lateral spread of metal artifacts in PBT slices as compared to DBT slices. Signal-to-noise ratio values for various inserts of the ACR and CD phantoms further validated the superiority of the PBT system. Mastectomy sample images acquired by the PBT system showed a superior depiction of microcalcifications vs the DBT system. Conclusion: The PBT imaging technology can be clinically employed for improving the accuracy of breast cancer screening and diagnosis.
  • Authors

    Published In

  • Medical Physics  Journal
  • Medical Physics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Ghani MU; Wu X; Fajardo LL; Jing Z; Wong MD; Zheng B; Omoumi F; Li Y; Yan A; Jenkins P
  • Start Page

  • 2511
  • End Page

  • 2520
  • Volume

  • 48
  • Issue

  • 5