Chlorophenols are very important environmental pollutants, which have created huge problems for both aquatic and terrestrial lives. Therefore, their removal needs urgent, effective, and advanced technologies to safeguard our environment for future generation. This review encompasses a comprehensive study of the applications of chlorophenols, their hazardous effects and photocatalytic degradation under light illumination. The effect of various factors such as pH and presence of different anions on the photocatalytic oxidation of chlorophenols have been elaborated comprehensively. The production of different oxidizing agents taking part in the photodegradation of chlorophenols are given a bird eye view. The photocatalytic degradation mechanism of different chlorophenols over various photocatalyts has been discussed in more detail and elaborated that how different photocatalysts degrade the same chlorophenols with the aid of different oxidizing agents produced during photocatalysis. Finally, a future perspective has been given to deal with the effective removal of these hazardous pollutants from the environment.