14-3-3 Proteins: Novel Pharmacological Targets in Neurodegenerative Diseases

Academic Article

Abstract

  • 14-3-3 proteins are a family of proteins expressed throughout the body and implicated in many diseases, from cancer to neurodegenerative disorders. While these proteins do not have direct enzymatic activity, they form a hub for many signaling pathways via protein–protein interactions (PPIs). 14-3-3 interactions have proven difficult to target with traditional pharmacological methods due to the unique nature of their binding. However, recent advances in compound development utilizing a range of tools, from thermodynamic binding site analysis to computational molecular modeling techniques, have opened the door to targeting these interactions. Compounds are already being developed targeting 14-3-3 interactions with potential therapeutic implication for neurodegenerative disorders, but challenges still remain in optimizing specificity and target engagement to avoid unintended negative consequences arising from targeting 14-3-3 signaling networks.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Pair FS; Yacoubian TA
  • Start Page

  • 226
  • End Page

  • 238
  • Volume

  • 42
  • Issue

  • 4