Influence of a low-dose cox-2 inhibitor drug on exercise-induced inflam-mation, muscle damage and lipid peroxidation

Academic Article


  • The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% ·VO2max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P<0.05). CK and CRP levels were significantly increased immediately, 3 h and 24 h after exercise in both groups (P<0.05). A significant increase in MDA was observed immediately after exercise in both groups (P<0.05); however, no significant group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid peroxidation.
  • Authors

    Published In

  • Biology of Sport  Journal
  • Digital Object Identifier (doi)

    Author List

  • Khoshkhahesh F; Siahkuhain M; Fisher G; Nakhostin-Rooh B
  • Start Page

  • 61
  • End Page

  • 65
  • Volume

  • 30
  • Issue

  • 1