Time-restricted feeding attenuates age-related cardiac decline in Drosophila.

Academic Article

Abstract

  • Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.

    • Authors

    Published In

  • Science  Journal

    • Keywords

  • Animals, Chaperonins, Circadian Clocks, Drosophila Proteins, Drosophila melanogaster, Electron Transport, Energy Intake, Feeding Behavior, Flight, Animal, Heart, Male, Metabolic Networks and Pathways, Mitochondria, Myocardial Contraction, Sleep, Transcriptome, Weight Gain

    • Digital Object Identifier (doi)

    Author List

  • Gill S; Le HD; Melkani GC; Panda S

    • Start Page

  • 1265

    • End Page

  • 1269

    • Volume

  • 347

    • Issue

  • 6227