A Role for Exercise to Counter Skeletal Muscle Clock Disruption

Academic Article


  • Disruption of the skeletal muscle circadian clock leads to a preferential shift toward lipid oxidation while reducing carbohydrate oxidation. These effects are apparent at the whole-body level,including glucose intolerance, increased energy expenditure, and fasting hyperglycemia. We hypothesize that exercise counters these metabolic disturbances by modifying the skeletal muscle clock andreverting substrate metabolism back toward an optimal substrate balance.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Erickson ML; Esser KA; Kraus WE; Buford TW; Redman LM
  • Start Page

  • 35
  • End Page

  • 41
  • Volume

  • 49
  • Issue

  • 1