Regulation of tumorigenic splicing by protein condensates with specific biophysical properties

Academic Article

Abstract

  • The role of biophysical properties of protein condensates in regulating gene expression and tumorigenesis remains unclear. We recently discovered that A-kinase anchoring protein 8 (AKAP8, also known as AKAP95), a RNA splicing regulator, supports tumorigenesis by forming liquid-like condensates, and that perturbing the biophysical properties of the condensates impairs its activity in regulating splicing and tumorigenesis.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Li W; Jiang H
  • Volume

  • 7
  • Issue

  • 6