© 2020, Springer Science+Business Media, LLC, part of Springer Nature. To date, most HIE studies have investigated user perceptions of value prior to use. Few studies have assessed factors associated with the value of HIE through its actual use. This study investigates provider perceptions on HIE comparing those who had prior experience vs those who had no experience with it. In so doing, we identify six constructs: prior use, system complexity, system concerns, public/population health, care delivery, and provider performance. This study uses a mixed methods approach to data collection. From 15 interviews of medical community leaders, a survey was constructed and administered to 263 clinicians. Descriptive statistics and analysis of variance was used, along with Tukey HSD tests for multiple comparisons. Results indicated providers whom previously used HIE had more positive perceptions about its benefits in terms of system complexity (p =.001), care delivery (p =.000), population health (p =.003), and provider performance (p =.005); women providers were more positive in terms of system concerns (p =.000); patient care (p =.031), and population health (p =.009); providers age 44–55 were more positive than older and younger groups in terms of patient care (p =.032), population health (p =.021), and provider performance (p =.014); while differences also existed across professional license groups (physician, nurse, other license, admin (no license)) for all five constructs (p <.05); and type of organization setting (hospital, ambulatory clinic, medical office, other) for three constructs including system concerns (p =.017), population health (p =.018), and provider performance (p =.018). There were no statistically significant differences found between groups based on a provider’s role in an organization (patient care, administration, teaching/research, other). Different provider perspectives about the value derived from HIE use exist depending on prior experience with HIE, age, gender, license (physician, nurse, other license, admin (no license)), and type of organization setting (hospital, ambulatory clinic, medical office, other). This study draws from the theory of planned behavior to understand factors related to physicians’ perceptions about HIE value, serving as a departure point for more detailed investigations of provider perceptions and behavior in regard to future HIE use and promoting interoperability.