Smoking and obesity relate to several leading causes of death in the U.S. and are common within the criminal justice system. Previous studies demonstrate links between smoking, obesity, depression, and race but have not examined all four variables together. The current study evaluated these relationships after a smoking cessation intervention. Participants (N=500) were recruited from community corrections. The Center for Epidemiological Studies Depression Scale (CES-D) measured depression. Self-reported number of cigarettes and weight and height measurements assessed smoking status and body mass index (BMI) at baseline and 12-month follow-up. Depression was associated with increased BMI. Among Blacks without depression, there was a significant relationship between smoking and BMI, such that greater smoking reduction was associated with greater weight gain. This is the first study to assess the interaction between race, smoking, BMI and depression. These findings support tailoring smoking cessation and depression interventions for different races.